Shaqiri made headlines during the 2018 World Cup in Russian Federation after celebrating his victor for Switzerland against Serbia by crossing his hands to imitate an eagle, which appears on Albania's flag.
The double-eagle is viewed as a symbol of defiance in Kosovo, which declared independence in 2008 in a move that Serbia still refuses to recognise.
Even before kick off, a heated atmosphere was anticipated, with Jurgen Klopp announcing he was leaving Kosovo-born winger Xherdan Shaqiri at home so as to "avoid distractions" in Serbia.
Red Star's sporting director, Zvezdan Terzic, cautioned against Shaqiri playing when the draw was earlier this year and the Klopp's decision has been welcomed by Serbian media and Red Star officials - who believe it has defused a potentially volatile situation and the threat of Uefa sanctions.
In 1999, Serbia allowed for North Atlantic Treaty Organisation intervention to crack down on the Albanian population within the country, leading to unrest that still exists today due to Kosovo not being recognised as an independent state.
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"We come here as a football team and we represent one of the biggest football clubs in the world".
"We have to make sure that we remain focused on football. We have no political message, absolutely not", Mr Klopp said. We want the focus to be on a great game of football, free from anything else.
When Red Star travelled to Anfield last month, Shaqiri was roundly jeered by the away fans, showing that his actions had certainly stayed fresh in the minds of some Serbians.
"So for that reason, he is not involved and he accepts and understands this".
Cascarino wrote for The Times: "Roberto Firmino looks to me like he needs a rest and I wouldn't be surprised to see Jurgen Klopp leave him out of one of the next few games".