They had symptoms of a respiratory illness in the week before developing symptoms of AFM.
UH said both patients have been discharged, but the Ohio Department of Health and the CC are continuing to monitor the illness.
AFM has been reported in 26 states in the USA, with a total of 85 cases and climbing.
Authorities say they have no confirmed cases of the nervous system condition called acute flaccid myelitis, or AFM, in NY.
In September, the Illinois Department of Public Health sent out an alert to health providers about AFM. "We'll continue to investigate and share information when we have it".
The reported IL cases are preliminary diagnoses and only the U.S. Centers for Disease Control can confirm the diagnosis, according to Arnold.
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Earlier this week, six children in Minnesota were diagnosed with this "rare" disease.
Doctors are reportedly hesitant to confirm cases of AFM, especially because it seems to follow a viral infection, which can have a range of specific neurological effects.
The number of cases has been increasing since 2014 with a total of 362.
The disease is not new but the cause remains unknown.
In 2014, 120 children were diagnosed with AFM. Symptoms typically include sudden weakness in one or more arms or legs, along with loss of muscle tone and decreased or absent reflexes.
Various viruses can cause AFM, including West Nile and enteroviruses. The cause of any individual case of AFM can be hard to determine, and often, no cause is found. CDC specialists will make the final determination if these cases are AFM. However, it recommends practicing disease prevention measures, including staying up-to-date on vaccines and protecting yourself from mosquito bites.