The longtime host of The Talk was missing from Monday's broadcast one week after she issued a statement saying she would be taking "a few days" off in the aftermath of her husband Les Moonves' firing from CBS.
It is said to have been the first time Chen has used her married name on the show shes been hosting for almost two decades.
Chen's co-hosts on the "The Talk" addressed the Moonves allegations last week.
Although Chen is leaving The Talk, as of now it looks as though she will be staying on as host of Big Brother.
Chen will announce the news to viewers of the CBS show on Tuesday via a pre-recorded video message.
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'Leslie is a good man and a loving father, devoted husband and inspiring corporate leader, ' she tweeted.
What do you think about the news of Julie Chen's The Talk resignation?
The sources said she made up her mind about leaving the talk show after spending time with her family late last week.
CBS has remained silent on Julie Chen Moonves' future on The Talk.
"He has always been a kind, decent and moral human being", Chen wrote in his defense this summer.
The statement she's referring to read, "I have known my husband, Leslie Moonves, since the late '90s, and I have been married to him for nearly 14 years". They said their source said she may have been asked to do so, and should be making the official announcement herself soon. I fully support my husband, and I stand behind him and his statement'. She didn't address her husband's scandal, but she did sign off from the show using her married name, Julie Chen Moonves, for the first time in her 18 years of hosting the CBS reality show. In the past, she had not used his last name.