The Serbian was in fine form as he overcame a spirited Kei Nishikori on Center Court as his comeback from injury continues to go from strength to strength.
'It feels great to be in the last four of a slam - I've been buiding on the last couple of weeks and the level of tennis I've played in the last couple of months, last couple of tournaments of the clay-court tournaments and Queen's, it kind of felt like it was getting better and better.
This is a 32nd Grand Slam semi-final appearance for Djokovic, although there was some doubt he would reach that mark.
Djokovic was frustrated at times during the match, receiving two code violations and accusing umpire Carlos Ramos of "double standards", but also showed plenty of signs he is returning to somewhere near his best.
After serving his way to a 2-1 lead in the third set, Djokovic ramped up his efforts and was met head-on with Nishikori's increase in tempo, but the No. 24 seed missed three break points at 2-2 and was soon trailing.
"I think it was great quality tennis and in the final set there were some awesome points", said Nadal who was a 7-5 6-7 4-6 6-4 6-4 victor.
'I didn't harm the grass.
Anderson hit 13 winners and just four unforced errors in the fourth set as he claimed the only break to force a decider.
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"You're saying in the point if I toss my racket like this I'm ruining the court?"
Djokovic secured that game with a forehand victor, then saved two game points on Nishikori's serve before converting his first match point with a forehand down the line. "In the midst of emotions in a tough match, it happens".
Nishikori, who had won only two matches in 15 meetings with the 12-time major victor, broke for 1-0 in the fourth but was broken straight back.
"Double standards, my friend", screamed the former world number one.
But the 12-times major victor regained his cool sufficiently enough to safely take his place in the semi-finals for the first time since snaring his third title at The All England Club in 2015.
After the match, Djokovic admitted his frustration at Ramos's decision, while pointing out that Nishikori did exactly the same thing in the fourth set.