Coverage: Watch live on BBC TV, BBC iPlayer, BBC Red Button, Connected TVs and the BBC Sport website and app; Live Radio 5 live and 5 live sports extra commentary; Text commentary online. Their last final was again in France in 2014, Nadal winning an epic.
Nadal carved out the crucial break in the opening set for a 6-5 lead and claimed the opener off a Del Potro backhand error.
Nadal worked the angles and moved superbly from the start, but the heavy-hitting Del Potro frustrated him by saving the first two break-point opportunities of the match before holding to level at 4-4.
Isner, who leads Anderson 8-3 in past meetings, is making his debut in the final four of a Grand Slam tournament in his 41st appearance at one.
Kevin Anderson celebrates beating Roger Federer on Wednesday.
So as Nadal and Djokovic continue their quest for yet another Wimbledon title, it's time for Federer to head home.
"It is always a big challenge facing Novak", said Nadal. I know Novak is playing great. "He's playing well. Only way to try to win it is (to) play very well".
Cotton: Democrats’ Opposition to Kavanaugh a ‘Laughable Political Game’
That line of thinking would be useful to Trump, who is unlikely to face impeachment so long as Republicans control Congress. Kavanaugh still lives in the D.C. area, raising his kids in the Maryland suburbs just miles from the White House.
"I've done a lot of things well since I am back from injury". I tried to resist and maintain focus.
Ten of the 11 matches between them were played on hard courts, while the only encounter on grass came at the Queen's Club in London in 2008, when Isner won in straight sets.
When he lost in the French Open quarter-finals to world number 72 Marco Cecchinato last month, he even suggested he was ready to skip Wimbledon this year as his ranking slipped to 22, his lowest since August 2006.
"Sorry to Juan Martin, he's an wonderful opponent and player".
So, too, did what happened next after Nadal won 7-5, 6-7 (7), 4-6, 6-4, 6-4 Wednesday and earned a trip to the semifinals at the All England Club for the first time since 2011: He went over to give del Potro a lengthy hug.
The 32-year-old's prize is a clash on Friday with first-time grand slam semi-finalist John Isner, who ousted 2016 runner-up Milos Raonic 6-7 (5-7) 7-6 (9-7) 6-4 6-3 in a serving shootout featuring 56 aces in four sets.
After seven weeks out with a serious knee injury, many doubted if Nadal would regain his crown as the "King of Clay".
A sprightly Nadal went on the front foot to turn the tide in the fourth, Del Potro twice hitting the deck as he was broken to love to trail 3-2 and while he saved two set points behind his powerful serve, the 11-time French Open champion was jumping for joy after a searing backhand victor made sure the match would go all the way.