The couple are already parents to daughter Luna, aged two, and previously revealed they were expecting a son.
The baby's arrival comes just a week after Teigen declared she was over being pregnant.
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Teigen discussed her past struggle with infertility in 2015 on her now canceled daytime talk show, FABLife.
She wrote: "Happy pregnant Chrissy is gone. meet OVER IT Chrissy". "Wanna hold my boy let's do thisssssss".
She added: "It feels worse for me because with IVF you know *so* early".
Congrats, Chrissy and John!