It is Abu Dhabi-owned City's third title in seven seasons and their first since former boss Manuel Pellegrini achieved the feat in 2013-14.
In his pre-match press conference on Friday, Mourinho told a journalist that he only needs four points to stay second and the derby win against Manchester City last week should set their hopes on course.
No action will be taken against Jay Rodriguez after the Football Association announced Friday that an allegation of racism against the West Bromwich Albion striker was "not proven".
Salomon Rondon saw a close-range header comfortably denied in the Baggies' other noteworthy first-half attempt, although United were taking their time to break down the brittle visitors.
For the millions (and millions) of pounds United spend on their attacking talent, with the likes of Romelu Lukaku, Alexis Sanchez and Paul Pogba starting against West Brom, the Red Devils lacked spark without their academy graduates Marcus Rashford and Jesse Lingard (in addition to Anthony Martial).
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Lukaku has gone from strength to strength following his stint at West Brom, enjoying a goal-laden spell with Everton before joining Man United last summer. United have won their last five league matches.
Nemanja Matic will also retain his place in the middle of the park and I think we might see Mourinho switch to a two-man midfield so Ander Herrera may drop back to the bench on Sunday despite his superb assist against City. He is expected to start out on the right-side ahead of Juan Mata.
But few would have predicted it coming against De Gea.
James McLean fired across face of goal and United failed to muster a leveller.
United pushed numbers forward in the closing stages, but Foster never really looked in danger of being tested again as United succumbed to a defeat that was celebrated by the blue half of Manchester with even more vigour than usual.